Antiviral Activity of low-MW Dextran Sulphate (Derived from dextran MW 1000) Compared to Dextran Sulphate Samples of Higher MW
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چکیده
منابع مشابه
Dextran sulphate--a synthetic analogue of heparin.
The structure of the natural anticoagulant, heparin, is gradually being elucidated. As each step forward is made, attempts to synthesize molecules with the biological activity of heparin receive renewed impetus. It is now known (Jorpes, 1939) that heparin is composed of glucuronic acid and glucosamine though the mode of linkage of these two parts is not yet clear. Some of the hydroxyl groups of...
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The renal clearance of [3H]dextran sulphate by the isolated perfused rat kidney was associated with desulphation of the molecule, as demonstrated by ion-exchange and affinity chromatography of material resident in both glomeruli and urine samples. This process also occurred in vivo. The molecular size distribution of glomerular dextran sulphate in the perfused kidney was indistinguishable from ...
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Persistent effects of a short course of intra-articular dextran sulphate, dextrans, or chondroitin sulphate were examined in rabbit knees. Only dextran sulphate produced gross arthritis, associated with high synovial acid phosphatase and beta-glucuronidase activities. Synovial degradative capacity in synovium-cartilage cocultures was increased 2-fold by dextran sulphate and 1.5-fold by chondroi...
متن کاملDextran sulphate: the relation of molecular features to biological properties.
In a previous paper (Ricketts, 1952a) a series of dextran sulphate preparations varying widely in molecular weight and sulphur content was described. The biological properties of these compounds were examined by Walton (1951, 1952), who found that molecular weight was the principal feature determining toxicity, the smaller molecules being the least toxic. At molecular weights (MN) of the order ...
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Studies of the effect of heparin injections on the serum lipoproteins of man and animals are in progress in several laboratories. Gofman and his collaborators have shown that heparin injection results in the larger lipoprotein complexes being converted to smaller ones as shown by the changes in ultra-centrifugal flotation patterns; see, for instance, Graham, Lyon, Gofman, Jones, Yankley, Simont...
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ژورنال
عنوان ژورنال: Antiviral Chemistry and Chemotherapy
سال: 1991
ISSN: 2040-2066,2040-2066
DOI: 10.1177/095632029100200307